Behavioral metabolomics analysis identifies novel neurochemical signatures in methamphetamine sensitization
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چکیده
منابع مشابه
Involvement of µ-Opioid Receptor in Methamphetamine-Induced Behavioral Sensitization
Methamphetamine is a potent addictive stimulant drug that activates certain systems in the brain. It is a member of the amphetamine family, but the effects of methamphetamine are much more potent, longer lasting, and more harmful to the central nervous system. Repeated administration of methamphetamine induces behavioral sensitization, which is considered to be related to compulsive drug-seekin...
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BACKGROUND The N-methyl-D-aspartate (NMDA) receptors play a role in behavioral abnormalities observed after administration of the psychostimulant, methamphetamine (METH). Serine racemase (SRR) is an enzyme which synthesizes D-serine, an endogenous co-agonist of NMDA receptors. Using Srr knock-out (KO) mice, we investigated the role of SRR on METH-induced behavioral abnormalities in mice. METH...
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ژورنال
عنوان ژورنال: Genes, Brain and Behavior
سال: 2013
ISSN: 1601-1848
DOI: 10.1111/gbb.12081